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Multifunctional Nanoparticle Developments in Lung Cancer

Multifunctional nanoparticles is promising system that can offer an opportunity to change the pharmacokinetic outline of drugs, diminish toxicity and enhance the therapeutic markers. Additionally, there is a robust prospect that cancer nanotechnology could also open up opportunities for screening cancer diagnosis and treatment approaches by means of multifunctional nanoparticles in four main zone: imaging of tumors, detection of cancer disease biomarkers, treatment modalities on the surface and in the core to targeting tumor cells, and monitoring of treatment to apply effective combinatorial therapeutic regimens against cancer (1) . In this blog, I would to explain more details about the usage of multifunctional nanoparticles in lung cancer and introduce different type of therapeutic nanoparticles.

Multifunctional Nanoparticle Developments in Lung Cancer

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Liposomes loaded with co-delivery of three different siRNA and one miRNA agents that use in active or passive loading scheme will enhance the formulation of combinatorial nanoparticles and the removal of unloaded drug. For lung cancer, using targeted liposomes to co-deliver DOX and DNA encoding can regulate mutant of survivin in human cancers. Survivin is a member of the inhibitor of apoptosis protein family inhibitor of apoptosis and is expressed in a large kind of malignancies (2). The liposomal drug delivery technique combined truncated basic fibroblast growth factor (TBFGF) peptides that identify BFGF receptors over expressed in lung cancer with DOX and pDNA encoding for the negative mutant of-survivin to counter survivin-mediated apoptosis resistance (3). Resulted Co-delivering equally chemotherapeutic agents produced an improved therapeutic response against Lewis lung carcinoma tumors–over liposomes with either agent alone. However, liposomes still face several limitations one of these is poor stability, so To enhanced the transfection efficiency of plasmid co-deliver DOX and DNA encoding I would coating a liposome with hydrophilic polymers to prevent liposome being adsorbed to plasma proteins and from being phagocytosed by macrophages (4).

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Another approach I have read, lung cancer targeted theranostic agent based on immunoliposome to inhibition of tumor growth and prevention of angiogenesis. Immunoliposome is carriers use for drug delivery, and it has ability to encapsulate in hydrophilic and hydrophobic therapeutic agents. In lung cancer, using an anti-c-Met single chain variable fragment (scFv) antibody was first identified by (Ms20, Kd value; 9.14 nM) (4). Cysteine residues were then merged for a site-direct combination with maleimide-modified PEG-terminated liposomal DOX. The final formulation resulted in Ms20-conjugated liposomal DOX due to enhance the chemotherapeutic drug delivery by inhibiting c-Met-transient or c-Met-constitutive activation of cancer cells (4). However, to improve delivery of the biodistribution of encapsulated agents, we need to take considerations of liposome, antibodies, and the chemotherapeutic agent. Liposomes with targeting antibodies can be achieved by crosslinking targeting antibodies to lipids or the terminal ends of PEG chains extending from the outer liposomal membrane. Also, the use of PEG can enhance circulation time but also reduce the proximity of adjacent antibody molecules on the surface of the liposome (5).

References

  1. Parvanian, Sepideh, Seyed Mojtaba Mostafavi, and Meysam Aghashiri. ‘Multifunctional nanoparticle developments in cancer diagnosis and treatment.’ Sensing and bio-sensing research 13 (2017): 81-87.
  2. Jaiswal, Praveen Kumar, Apul Goel, and R.D. Mittal. “Survivin: A Molecular Biomarker in Cancer.” The Indian Journal of Medical Research 141.4 (2015): 389–397. PMC. Web. 16 Oct. 2018.
  3. Glasgow, Micah D. K., and Mahavir B. Chougule. “Recent Developments in Active Tumor Targeted Multifunctional Nanoparticles for Combination Chemotherapy in Cancer Treatment and Imaging.” Journal of biomedical nanotechnology 11.11 (2015): 1859–1898. Print.
  4. Wang, Wenxi, et al. ‘Cationic polymethacrylate-modified liposomes significantly enhanced doxorubicin delivery and antitumor activity.’ Scientific reports 7 (2017): 43036.
  5. Brown, Brandon S et al. “Etoposide-Loaded Immunoliposomes as Active Targeting Agents for GD2-Positive Malignancies.” Cancer Biology & Therapy15.7 (2014): 851–861. PMC. Web. 17 Oct. 2018.

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Multifunctional Nanoparticle Developments in Lung Cancer
Artscolumbia
Artscolumbia
Multifunctional nanoparticles is promising system that can offer an opportunity to change the pharmacokinetic outline of drugs, diminish toxicity and enhance the therapeutic markers. Additionally, there is a robust prospect that cancer nanotechnology could also open up opportunities for screening cancer diagnosis and treatment approaches by means of multifunctional nanoparticles in four main zone: imaging of tumors, detection of cancer disease biomarkers, treatment modalities on the surface and
2022-04-18 04:33:57
Multifunctional Nanoparticle Developments in Lung Cancer
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